Examples of the different uses in various products are shown in the table below: Sodium lauryl sulfate has been used in pharmaceutical and personal care products for several decades. 121CFR 172.822 2Tentative Final Monograph 21CFR 356 376/768/EEC, Privacy Policy Terms of Sale Terms of Use Children's Privacy Policy Cookie Policy Cookie Consent Tool. Many of these ingredients would not be considered by Toms of Maine because they fail to meet our Stewardship Model guidelines. In the pharmacopoeia, Sodium lauryl sulfate is described as a mixture of sodium alkyl sulfates, consisting chiefly of sodium lauryl sulfate [CH3(CH2)10CH2OSO3Na]. That is, new products being tested to see how irritating they might be to human skin are compared to SLS - something we know definitely to be irritating. There are many safer alternatives available (look for fatty alcohol ethoxylate, alkyl phenol ethoxylate or fatty acid alkoxylate on the label). Toms of Maine recognizes that no two people are alike, and even with naturally derived ingredients, some individuals may develop an allergic reaction that is unique to them. The lauryl alcohol is then combined with sulfur which then forms the salt, sodium lauryl sulfate. It has to have been found in studies to irritate human skin, and it has to have the ability to penetrate the skin. Inhalation and contact with the skin and eyes should be avoided. SLS is approved for use as a direct additive to food by the United States Food and Drug Administration (FDA) when used as a surfactant, whipping and wetting agent or as an emulsifier1. Sodium lauryl sulfate can interact with cationic surfactants, leading to decreased activity. It typically appears as a white or cream colored crystal or powder. It has been shown that when skin is repeatedly exposed to Sodium lauryl sulfate, xeroderma (drying and cracking of skin) may occur. Oh no! It may also serve as an emulsifier, helping oil based and water based ingredients to stay mixed. In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms. The lauric acid is isolated and then hydrogenated to form the lauryl alcohol. It is also GRAS listed and included in the FDA Inactive Ingredients Database. SLS ticks both of these boxes. Last updated on Jun 6, 2022. It may also be called sodium dodecyl sulfate; dodecyl sulfate, sodium salt; and sodium n-dodecyl sulfate. However, in animal studies sodium lauryl sulfate has been shown to be irritating to the eyes and skin when applied topically. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Sodium Lauryl Sulfate also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate is a synthetic organic compound widely used in personal care products as an anionic surfactant. That something is called a surfactant. In 2003, the US Department of Health and Human Services evaluated the safety of SLS concluding that SLS is safe for use in oral care products2. It is similarly used in pharmaceutical products taking advantage of its surfactancy properties. http://www.mayoclinic.com/health/canker-sore/DS00354/DSECTION=causes. So products that will be on the skin for a prolonged time can contain no more than 0.05-2.5% SLS in most countries. The workspace should provide adequate ventilation and/or a dust respirator should be used. Its also important to note theres no scientific evidence SLS causes cancer, despite what you may read on the internet. It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. Pharmacopoeial Compliance: USP-NF; Ph.Eur; B.P; J.P; I.P, Synonyms and Trade Names: Sodium Lauryl Sulphate; Sodium Lauryl Sulfate; SLS; Sodium Dodecyl Sulfate; SDS; Dodecyl Alcohol Hydrogen Sulfate, Sodium Salt Dodecyl Sulfate; Lauryl Sodium sulfate; Lauryl Sulfate, Sodium Salt; Monododecyl Sodium Sulfate; Sodium Dodecyl Sulfate; Sodium n-dodecyl Sulfate; Sodium Laurilsulfate; Sodium Monododecyl Sulfate; Sulfuric Acid Monododecyl Ester, Sodium Salt; Texapon KI2P; Elfan 240, Uses: Ionic Surfactant; Tablet Lubricant; Solubiliser; and Dissolution Rate Enhancer. F. Zhao, V. Malayev, V. Rao, M. Hussain, Effect of sodium lauryl sulfate in dissolution media on dissolution of hard gelatin capsule shells, Pharm Res, 21 (2004) 144-148. While an approved excipient, Sodium lauryl sulfate is fairly harmful and acutely irritant to mucous membranes (eyes, upper respiratory tract and stomach). Cook, C.G. Consult the MSDS for more detailed information. Another study found the warmer the water used with SLS, the more irritating it will be. Sodium lauryl sulfate is frequently confused with sodium laureth sulfate, but the two are distinct ingredients. Sodium lauryl sulfate is used in a variety of products, and has a long history of safe use. Health Check: what should I eat to improve my skin? Accessed on August 30, 2011. period: 24 Toxicology: Human lethal oral dose is reported to be 0.5-5.0 g/kg body-weight. It typically appears as a white or cream colored crystal or powder. Learn more about this chemical, such as how it works and whether it's safe. Medically reviewed by Drugs.com. For something to be harmful, irritant or allergenic, it has to fulfil two criteria. It is used in solid dosage forms and topical products largely due to its surface-active properties. Many other surfactants agents exist, including synthetic alternatives and additional naturally derived ones. [3] G. Heinicke, J.B. Schwartz, The influence of surfactants and additives on drug release from a cationic Eudragit coated multiparticulate diltiazem formulation, Pharm Dev Technol, 12 (2007) 381-389. }); PharmaCentral.com may on occasion publish user-generated content. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. India Sodium Lauryl Ether Sulfate [SLES] Market demand was valued 236 Thousand Tonns in 2020 and is expected to reach 401 Thousand Tonns by 2027, at CAGR of 7.9% during forecast period of 2021 to 2027. In the Ph.Eur, Sodium lauryl sulfate is described as a mixture of sodium alkyl sulfates and consists mainly of Sodium lauryl sulfate (chemical formula, CH3(CH2)10CH2OSO3Na). SLS is also permitted for use in all cosmetics in the European Union (EU) without restrictions3. I. Rantanen, K. Jutila, I. Nicander, J. Tenovuo, E. Sderling, The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo, Swedish dental journal, 27 (2003) 31-34. Our Stewardship Model guides us to select ingredients which have been processed in a manner that supports our philosophy of human and environmental health. Sodium lauryl sulfate is frequently used as a surfactant, or foaming agent. Canker Sore: Causes. The Ph.Eur and B.P specified the assay content of Sodium lauryl sulfate which should be not less than 85% of sodium alkyl sulfates calculated as C12H25NaO4S. It's essentially a synthetic soap. [2] J. Hanaee, Y. Javadzadeh, S. Taftachi, D. Farid, A. Nokhodchi, The role of various surfactants on the release of salbutamol from suppositories, Farmaco, 59 (2004) 903-906. PharmaCentral 2021 . Sodium lauryl sulfate (C12H25SO4Na) is a surface-active agent used in cleaning and cosmetic products. Available for Android and iOS devices. Skin care products also have hotline numbers on the packaging that can be contacted to report adverse effects. It is used in industrial strength degreasers, floor cleaners, bubble bath and toothpastes. Under Section 107 of the Copyright Act 1976, allowance is made for Fair Use for purposes such as criticism, comment, news, reporting, scholarship, education, and research. So if its known to be irritating to human skin, why dont the regulatory authorities ban its use? Generally, with consumer products such as washes that contain SLS, its assumed they wont be on the skin for very long, meaning the chance of your skin being affected is pretty low. Molecular Formula CHNaOS. Sodium lauryl sulfate is frequently confused with sodium laureth sulfate, but the two are distinct . In fact, SLS is so known to cause irritation, its used as a positive control in dermatological testing. Stepanol WA 100 Elemental Impurities Statement. In many of our toothpastes SLS is used as a surfactant and helps to properly disperse the ingredients during brushing, and ensures easy rinsing and removal of debris (i.e. Using a chemical that weakens this defence mechanism can potentially cause our skin harm. Your toothpaste, shampoo and body wash probably all contain SLS. Sodium laureth sulfate (SLES), an accepted contraction of sodium lauryl ether sulfate (SLES), also called sodium alkylethersulfate, is an anionic detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste, etc.) Our skins outermost layer is specially designed to keep harmful stuff out, and this is where a surfactant can cause problems. A surfactant allows the oil and water molecules to bind together its whats found in soaps and detergents so we can wash our oily faces or dishes with water and get the grime to disappear. Use of eye protection, gloves, and other suitable PPE are advised. It is an anionic surfactant as defined by the sulfate head group . food particles). So on products containing SLS, you should see something like if this product causes any skin redness or irritation, discontinue use and consult a medical practitioner. Learn more about what it is, why it is used, and if it is safe to use it. Your toothpaste . Sodium lauryl sulfate is a fairly stable excipient under standard storage conditions. We use SLS in many of our products because of its long history of safe and effective use, and because of the volume of scientific substantiation for its safety. Any information provided on our platform is for general informational and educational purposes only. Sodium laureth sulfate | C14H29NaO5S | CID 23665884 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Sodium lauryl sulfate may be derived from either petroleum based or vegetable based sources. Sodium lauryl sulfate is prepared by reacting sulfuric acid with lauryl alcohol, followed with the addition of sodium carbonate to produce sodium lauryl sulfate. SLS is approved for use as a direct additive to food by the United States Food and Drug Administration (FDA) when used as a surfactant, whipping and wetting agent or as an emulsifier. It has a smooth, slippery (soapy) feel when rubbed between fingers and a perceptible odour of lipids. This can happen even when the concentrations of either species are very low. When handling the material, workers should observe standard SHEQ protocols in line with the circumstances and quantity of material being processed. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. mode: "every-time", Sodium Lauryl Sulfate (also referred to as Sodium laurilsulfate or Sodium dodecyl sulfate) is a synthetic organic compound widely used as an excipient and in personal care products as an anionic surfactant. Our Botanically Bright and Botanically Fresh toothpastes use our best performing SLS alternative, a blend of Sodium Cocoyl Glutamate and Lauryl glucoside, which are other naturally derived dispersants from coconut or palm kernel oil and corn. In the pharmaceutical industry, it has been used as an excipient in dissolvable dosage forms. Read more: SLES is the most common of a group of commercial sodium and ammonium alkyl and alkyl ether sulfates. 151-21-3 - DBMJMQXJHONAFJ-UHFFFAOYSA-M - Sodium lauryl sulfate [JAN:NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Sheskey, W.G. Of all the ingredients we use, Toms of Maine tends to receive the highest volume of questions about our use of SLS. Sodium lauryl sulfate (SLS) is found in shampoos, soaps, various beauty and cleaning products, and even some foods. As with any product, be sure to discontinue use if you experience discomfort or other indications that the product may not be appropriate for your individual body chemistry. It has a perceptible lipid odour. In solution, Sodium lauryl sulfate may undergo hydrolysis to lauryl alcohol and sodium bisulfate when pH falls significantly (e.g < pH 2). Sodium lauryl sulfate (SLS) is the sodium salt of lauryl sulfate. The views expressed here are those of the author and do not reflect the official policies of the U.S. Food and Drug Administration. All information is provided in good faith to enable collaboration and sharing of know-how among our community of users. However, for consumers who prefer to use a product without SLS, we offer some SLS-free alternatives. Excipient (pharmacologically inactive substance). This may partly be fueled by the volume of misinformation currently available on the internet. It may also be used to aid the dissolution rate of poorly soluble active substances during dissolution test measurements. What are hives, the common skin condition that gives you itchy, red bumps? In formulated products, Sodium lauryl sulfate is incompatible with salts of polyvalent metal ions (e.g Aluminium, Zinc, and Magnesium). It is supplied as white or whitish-coloured crystals, powder or flaky material, with a slippery feel upon rubbing between fingers.
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sodium lauryl sulphate formula